Functional quinoline-malononitriles for enhanced wound repair and monitoring

Abstract

Wound healing is a complex biological process that, when disrupted, can result in chronic wounds and substantial healthcare burdens. Materials that enhance wound repair while enabling real-time monitoring represent a significant advancement in wound management. In this study, we report a series of fluorescent quinoline-malononitrile (QM) derivatives with aggregate-induced emission (AIE) properties and evaluate their therapeutic potential in dermal and epidermal cell models. Cytotoxicity assays revealed selective proliferative and anti-proliferative effects across different QM analogues. Notably, QOne (1) and MeQM (4) promoted keratinocyte proliferation, a critical step in re-epithelialisatio..